Sediment cells from cell blocks can be more useful than the routine cytological methods for body fluids. The present study was conducted to compare cell block and cytological methods of body fluids. Two-year study was done in a tertiary care hospital of Punjab. Samples were taken from 90 patients, comprising 30 Ascitic, 30 Broncho alveolar lavage (BAL), and 30 pleural fluids. Cytology smears were prepared & stained with H & E stain and cellblock preparations of centrifuged deposits were processed, then sections were cut with 5 micrometers and stained with H & E stain. Sensitivity of cell blocks was found to be nearly double that of routine cytology. Cell blocks are proved to be superior to the cytological smears, when there is need for Immunohistochemistry. Use of cell blocks plays a vital role than routine cytology smears of body fluids can increase the sensitivity.