Depressive disorder is one of the most commonly found non-communicable types of clinical disorder having serious impact, not only on the mental health status; but also on the health and socio-economic status of the concerned person. Though reason for depressive disorder is not conned to a particular reason, a wide range of chronic health issues, socio-demographic conditions, and even the family background have major impact on its occurrence. Patterns of intervention management in both adults and children involve psychotherapy with some specically designed self-help tools. In peculiar cases, depending upon the severity of depression, antidepressants can be used in pharmacotherapy. The current study meta- analysis is a systematic review analysis of depressive disorder causes in both adults and children through the validation of the assessment tools involved in measuring the severity and the types of interventions used by expert clinicians, to provide better cure of diseases.