Z ZFifteen new pyridazine and phthalazine derivatives were prepared (in good to excellent yields) and tested in vitro as antimicrobial compounds. All the compounds have proved to have a remarkable activity against Gram positive germs, the results on Sarciria Luteea being spectacular. Correlation structurebiological activity have been done. Stereo-and region-chemistry involved in these reactions are discussed.

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Activity. -Novel heterocyclic compounds such as (III), (V), (VII), (IX) and (XI) are tested in vitro as antimicrobial compounds. Pyridazine and phthalazine derivatives exhibit excellent effects against Gram-positive germs. -(BUTNARIU, R. M.; CAPROSU, M. D.; BEJAN, V.; UNGUREANU, M.; POIATA, A.; TUCHILUS, C.; FLORESCU, M.; MANGALAGIU*, I. I.; J. Heterocycl. Chem. 44 (2007) 5, 1149-1152; Dep. Org. Chem., Al. I. Cuza Univ., RO-700506 Iasi, Rom.; Eng.) -K. Schneider 04-168