Type II Diabetes Mellitus or Non-Insulin dependent Diabetes mellitus (NIDDM) is one of the common diseases worldwide and often recognized as life style disease. The major symptom of this disease is an increase in blood glucose level resulting in polydypsia, polyuria and polyphagia. The cause of this abnormality is either lack of insulin production or insensitivity to the insulin produced inside the body. Glucagon like peptide (GLP) produced by the glucagons gene is responsible for insulin secretion. Thus proper functioning of GLP can be a remedy for Type II Diabetes mellitus. DiPeptidyl Peptidase IV (DPPIV) checks the GLP, thus in order to restore the normal functioning of these, the activity of DPP IV has to be checked using DPP IV inhibitors. In this paper the target sequence was retrieved, modeled using modeller 8vl followed by validation by PROCHECK. Ligand molecule was constructed by LIGBUILDER. Docking was carried out with methylamine as a lead molecule and DPPIV as receptor to design a drug molecule. Designing of a drug molecule was followed by screening for its activity and drug likeness. The present studies provide new insights for efficient inhibition of DPP IV to restore the normal activity of the body overcoming the negative effects left by other drugs.

We investigated the anti-edema effect of intravenous dexamethasone in a randomized, double-blinded, placebo-controlled study in 40 ASA physical status I and II patients scheduled for trans-oral decompression and posterior fusion. Patients were divided into two groups to receive either placebo or 10 mg dexamethasone one hour prior to induction of anesthesia. After anesthesia induction, oral structures were graded as swelling grade 0 at direct laryngoscopy. Duration of trans-oral surgery, duration of posterior fusion, and total duration of surgery were recorded. After completion of surgery, direct laryngoscopy was repeated, and swelling was graded from 1 to 4. Patients who had a swelling grade of 1 or 2 were extubated while grades of 3 and 4 were transferred to a neurosurgical intensive care unit, and re-assessments were performed 12 hours apart. Patients with swelling grades of 1 and 2 were extubated on each assessment. On statistical analysis of the results, the study found that in comparison to placebo, patients in the dexamethasone group were extubated earlier (P < 0.006, Chi Square for trend). Total duration of surgery and duration of posterior fusion were significantly greater (P < 0.05) in patients who had swelling grade >2 than in patients who had swelling grade < or =2 at completion of surgery (192.50 +/- 16.26, 356.07 +/- 17.06 minutes versus. 158.27 +/- 9.07, 311.41 +/- 14.06 minutes).

No abstract

No abstract

No abstract