Diabetic is a metabolic disorder disease leading to hyperglycemia because of lack of insulin secretion or inadequate of insulin activity. Indonesia has 9.600 plant species that have been used for health care and treatment of various diseases. Diabetic patients can experience a problem in the form of foot blood vessels disorders and if not treated properly will become wounds that are difficult to heal and easily develop into gangrene which is high risk of amputation. Therefore, this journal will discuss natural remedies that can be used as a treatment in patients with diabetic wounds and several pharmacological testing performed for testing the diabetic wound healing activity. Various kinds of natural remedies such as Andredera cordifolia, Centella asiatica, Curcuma longa, Carica papaya and hone are proven to accelerate diabetic wound healing through various mechanisms.