Article Extended Data Fig. 7 | Analysis of 2019-nCoV receptor usage. Determination of virus infectivity in HeLa cells with or without the expression of human APN and DPP4. The expression of ACE2, APN and DPP4 plasmids with S tag were detected using mouse anti-S tag monoclonal antibody. ACE2, APN and DPP4 proteins (green), viral protein (red) and nuclei (blue) are shown. Scale bars, 10 μm.

Synthesis of multifunctional magnetic nanoparticles (MFMNPs) is one of the most active research areas in advanced materials. MFMNPs that have magnetic properties and other functionalities have been demonstrated to show great promise as multimodality imaging probes. Their multifunctional surfaces also allow rational conjugations of biological and drug molecules,making it possible to achieve target-specific diagnostics and therapeutics.This review fi rst outlines the synthesis of MNPs of metal oxides and alloy sand then focuses on recent developments in the fabrication of MFMNPs of core/shell, dumbbell, and composite hybrid type. It also summarizes the general strategies applied for NP surface functionalization. The review further highlights some exciting examples of these MFMNPs for multimodality imaging and for target-specific drug/gene delivery applications.

Highlights d SARS-CoV-2 could infect HFH4-hACE2 mice and cause death d SARS-CoV-2 infection localizes to lungs of mice and causes typical interstitial pneumonia d Pre-exposure to SARS-CoV-2 protects mice from lethal challenge