Fluorine-containing b-amino acids and their derivatives have attracted significant attention due to their importance in life sciences.H erein the previously unknown difluoroketenimine,t he analogue of the elusive difluoroketene,h as been generated by the reaction of difluorocarbene and isocyanide,w hich further undergoes [2+ +2] cycloaddition with imine.T he three-component reaction affords a,adifluoro-b-amino amides in good yields.M echanistic studies reveal the unique properties of the difluoroketenimine in the [2+ +2] cycloaddition with imine. Scheme 1. Staudinger synthesis and proposed [2+ +2] cycloaddition with difluoroketenimine.