A 2320-g male infant was delivered at 35 weeks gestation to a mother who had polyhydramnios. He had a combination of congenital localized absence of skin, unilateral hydronephrosis, and hydroureter due to ureterovesical obstruction, and nonbilious vomiting due to pyloric atresia. Blistering of the skin developed after birth. Epidermolysis bullosa simplex was confirmed by electron microscopy of a skin biopsy specimen. We describe this patient, who had three unusual manifestations of epidermolysis bullosa.

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Background and aims: Leukotrienes are major inflammatory mediators in wheezing-LRI and leukotriene antagonist has been reported to be effective in asthmatic children. This randomized double-blind, placebocontrolled trial study was performed to evaluate the efficacy of montelukast in the treatment of wheezing-LRI and in prevention of recurrent wheezing among previously healthy children under 5 years of age with risk of asthma.