Background: Deep Vein Thrombosis may lead to many complications like Pulmonary embolism (PE), Postphlebitic syndrome and Treatment complications like Bleeding (haemorrhage) as a side effect of blood thinners. The knowledge of health care providers, especially the nurses would make a significant impact in the early risk identification speedy recovery and prevention of these complications. Materials and Methods: A quantitative research approach was adopted for the study. A one group pre-test and post-test experimental design was used to determine the effect of planned teaching program on knowledge of staff nurses. The study comprised of 40 nursing interns working in a selected Hospital who fulfilled inclusive criteria drawn by Convenient Sampling method. A self-administered knowledge questionnaire was used for data collection. The content Validity of the tool was established in consultation with guide and 12 experts from the field of Medical Surgical Nursing, an educationist and a statistician. Reliability coefficient of knowledge questionnaire was calculated using the Karl Pearson correlation coefficient method. Further, a formal permission was obtained from authority concerned from selected hospital for data collection. Then, the Collected data were tabulated and analyzed. Results: The study revealed that the mean score among nurses was 10.5 (42%) during pre-test rose up to 20(80%) in the post-test evaluation. Result interpreted that there was a significant increase in knowledge level of nursing interns after administration of the intervention. It is evident that the calculated’ value was greater than the table value of ‘t’ at 0.05 level. This indicates that Planned teaching program was effective in improving the knowledge of the nursing interns. Conclusion: The study was done to assess the effectiveness of planned teaching program on prevention of Deep Vein Thrombosis among nursing interns. The result of this study shows that the most of the nursing interns had excellent knowledge after administration of planned teaching program. Hence, it can be concluded that the planned teaching program was found good method for achieving knowledge on DVT and its prevention. Key words: planned teaching program, knowledge, Deep Vein Thrombosis