The fermented products from milk whey(PS-H1)was cultivated using of Lactobacillus,Lactococcus,Streptococcus,Leuconostoc,Acetobacter and Saccharomyces ets.The hypocholesterolemic effect of the PS-H1 was examined in the rats fed a high cholesterol diet.The atherogenic diets containing 1%PS-Hl was given to four-weekold wistar rats for 28 days.After 28 days of feeding,serum total cholesterol concentration was significantly lowered in the rats fed PS-H1 group than control group,but there were no significant difference in the liver cholesterol among the group.There was a higher concentration of Albumin,IgG and IgA in serum of the PS-H1 group compared control group. We suggest the possible presence of a component in the PS-H1 which promotes the activation of protein synthesis in the liver.