No abstract

A case of erythema elevatum diutinum, unresponsive to dapsone but successfully treated with colchicine, is described.

Iontophoresis was used to evaluate the peripheral reactivity of phenylephrine (α₁-agonist), isoproterenol (β-agonist) and metacholine (cholinergic agonist) in patients with Alzheimer’s disease (AD). The cutaneous responses – erythema and blanching – were visually recorded. Healthy personnel, medical students and patients with various dermatoses served as controls. A reduced response towards the adrenergic agonists was seen in AD. The reduced sensitivity was highly significant for the β-agonist isoproterenol (p < 0.001), in contradistinction the metacholine response did not differ between AD and age-matched controls. Furthermore, increasing age did not seem to significantly influence the cutaneous responses in mentally healthy controls. Thus, a reduced peripheral adrenergic reactivity was observed in the patients suffering from AD.

No abstract

not available