Controlled hypotensive anesthesia is essential during FESS surgeries for better view of surgical field. This study is conducted to compare Dexmedetomidine and Fentanyl-Propofol groups for controlled hypotensive anesthesia. A prospective, randomized, single blinded study was conducted on 50 ASA 1 or 2 patients undergoing Functional Endoscopic Sinus Surgery. Patients were randomly divided into 2 groups. Patients in Group 1 were administered Dexmedetomidine loading dose of 1μg/kg in 20 min followed by infusion of 0.5-0.7μg/kg/hr. and patients in Group 2 were administered Fentanyl 2μg/kg preoperatively and Propofol infusion (80-100μg/kg/min) intraoperatively. Pulse rate, Blood pressure was recorded for every 5 min throughout the intraoperative period and quality of surgical field was assessed by "surgeons scale for assessment difference of quality of surgical field". There was no statistically significant between the two groups regarding hemodynamic parameters or quality of surgical field. CONCLUSION: Both Dexmedetomidine & Fentanyl-Propofol are good and effective in achieving bloodless visually improved surgical fields. The only advantage with Dexmedetomidine is that it has got inherent analgesic, sedative & anesthetic sparing properties which avoid administration of multiple drugs.