A study aimed to examine immunomodulatory effect of concentrated cell free filtrate (CCF) of Lactobacillus acidophilus on immune system of mice by detecting the total and absolute counts of leucocytes. It was shown that CCF of Lactobacillus acidophilus caused a significant increase in total leucocyte count for all concentrations used in comparison with negative control. However, in absolute leucocyte counts the, CCF of L.acidophilus at doses (500 , 750) mg/kg caused a significant increased in lymphocyte, neutrophil and monocyte counts, while there was no significant differences in eosinophils and basophil cells number of mice treated with bacterial filtrate. The interaction study showed that the post-treatment with CCF of L. acidophilus caused a significant increase in total leucocytes count and absolute counts of all types of leucocyte cells except basophils and esinophils which showed no significant differences in comparison with pre-treatment

This study dealt with the effect of Lactobacillus acidophilus concentrated filtrate on polychromatic erythrocyte. The result showed that Lactobacillus acidophilus concentrated filtrate caused a non significant decrease in micronucleus formation at first dose in comparison with negative control while a significant decrease in micronucleus formation was shown in albino male mice at second and third doses in comparison with negative and positive controls. The result of post-treatment by concentrated filtrate also caused a significant decrease in micronucleus formation while the pre-treatment caused non significant decrease in the micronucleus formation in comparison with the corresponding control.