The first applications of a novel polyanionic derivative of (S-cycIodextrin (/3-CD), sulfobutyl ether ß-CO (ß-CO-SBE(IV)), as a stereoisomer selector in capillary electrophoresis are described. Separations were developed for one and two chiral molecules, including (±)-ephedrine, (±)pseudoephedrine, and several structurally related compounds.The separations achieved were found to be superior to those possible with neutral selectors such as ß-CO or heptakis(2,6dimethyl)-/8-CD. Base line separation of the four stereoisomers of (±)-ephedrine and (±)-pseudoephedrine was achieved in a single run with /S-CD-SBE(IV). Aspects regarding structural specificity, binding magnitude, and the utility of having a stereoisomer selector with a large countercurrent mobility are discussed.

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Bioerodable polyester-polyurethane polymer coatings containing levofloxacin can prevent bacterial colonization of implants in an intra-operative model of device-related infections.

The synthesis of biocompatible polymer diclofenac conjugates (PDCs) that have a high drug loading and high degree of control over diclofenac (DCF) release is described.

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