The article considers some issues of institutional support for developing regional business environment as the basis of successful economic development of a region. The process of regional business environment institutions forming is analyzed using the methodology of constructing a matrix-based institutional model of entrepreneurial activities. The authors conclude that it is the institutional configuration of business environment that accounts for the existing discrepancies in the levels of social and economic development among regions. Applying the instruments of institutional projecting the authors construct models of interaction between business entities and regional authorities in the context of newly introduced rules of running a business that allows to determine the parameters of optimal institutional configurations of regional business environment.
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