An odontogenic infection is an infection that originates within a tooth or in the closely surrounding tissues. In vitro quantitative evaluation of. IL-6, INF-gamma and CD4 and. CD8 molecules during odontogenic infection and control. group. In vitro quantitative determination of, IL-6,INF-gamma and CD4 and CD8 molecules in serum using Sandwich-ELISA. the Mean±SD of serum IL-6 was 41.1450±19.802 (pg\ml) for patients and 10.367±4.047 pg\ml for healthy with P. value 0.0001, while the Mean±SD of serum IFN-ɣ was higher in control group than in test group (61.490±30.662) (pg\ml) and 16.880±7.593 (pg\ml) respectively. and the differences were significant, P 0.0001. At the same time, The mean of serum CD4 molecules was 5.175±2.335 (ng\ml) and 2.230±1.027 (ng\ml) for controls groups with P. value was ≤0.0001. while serum soluble CD8 was the Mean±SD 3.265±1.175 (ng\ml) and 1.014±0.815 (ng\ml) for controls healthy with P. value ≤ 0.0001. Mean of the CD4/CD8 ratio was 1.584 in control group while it was 2.199 in odontogenic infection patients" Conclusion: Immunological parameters were included in present study ( IL-6, IFN-ɣ, CD4 and CD8,) showed high levels among patients with odontogenic infection compared to a healthy control.

Odontogenic infection is an infection that originates within a teeth and the closely surrounding tissues as the dental pulp, jawbones, periodontium, or in closely surrounding tissue. This study aimed to isolate and detect bacteria associated with odontogenic infections and identify antimicrobial susceptibility against predominant bacterial isolates.Atotal of 30 pus samples were collected by aspiration and placed in transport media. "These pus samples subjected to different methods for identification of bacteria using traditional bacteriological method". The antimicrobial liability of isolated bacteria was determined by using disc diffusion method.Predominant isolated bacteria was Streptococcusviridians group (36%) followed by S. aureus (26.2%) and lowest percentage of isolated bacteria was black pigmented bacteria(Prevotella and Porphyromonasspp), in addition to K. Pneumonia and E. coli. The results showed very high susceptibility of isolates to amoxicillin (97%) followed by cefotaxime and imipenem (94%). Whereas the lowest sensitivity was detected to clindamycin (18%).The present results approve the existence of mixed bacterial infection with the predominance of Streptococcusviridans. Most Streptococcusviridans were inhibited by amoxicillin followed by cefotaxime and imipenem.