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Intraocular pressure (IOP) is usually measured by methods necessitating the use of local anesthetic drugs. The effect of these agents on IOP is the subject of this study. We have measured IOP with a noncontact tonometer before and after application of a local anesthetic solution to one eye, the other eye serving as a control. A reduction of pressure occurred in the treated eye, but it is concluded that for practical purposes, local anesthesia does not falsify the results of IOP measurements.