These antibodies are high-titered and have low avidity, they are red cell, white cell antibodies, they are clinically insignificant, are not reactive with enzyme-treated red cells, and can be absorbed with white cells!" Then the chorus of other blind, wise blood bankers said, "NO, THEY ARE NOT!" based on memories of discussions about these antibodies back in the 1970s and the fable of the elephant and blind wise men-r. mougey

This update of the Chido/Rodgers blood group system (Mougey R. A review of the Chido/Rodgers blood group. Immunohematology 2010;26:30-8) summarizes the current understanding of the genetics and serology of this blood group (of which little has changed since the publication of the first review) in a table format as well as summarizes the gene frequencies and disease association with low copy number of C4A or C4B genes. The International Society of Blood Transfusion (ISBT) has designated the ISBT number 017 to this system and the abbreviation CH/RG for the antigen or antibody notation. There are currently nine antigens in the CH/RG system. A brief discussion on the serologic challenges of detecting the antibodies and of newer information on the disease associations is provided. This review concludes with some speculation on how our understanding of C4 genes may be illuminated by current investigation into complexities of autoimmunity and the role of C4 and its progression to a disease state.

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