Problems in the medical supply chain are neither new nor uncommon: These products can travel through global supply chains in which documentation is often manual and paper-based, increasing at each handoff and border crossing. As a result, theft and quality control issues are common, and regulators and distributors struggle to locate substandard products that have entered the system. As both the technology and the industry’s processes for working together matures, blockchains could help us get better and faster at getting medicines and vaccines to where we have the most urgency. With more granular visibility, stakeholders could better zero in on clogs in supply chains, more quickly locate and remove expired, damaged, or fraudulent products.