The electrochemical signal from ferrocene on a DNA probe was successfully modulated in a homogeneous solution by template-directed formation and dissociation of an inclusion complex with β-cyclodextrin on another probe. The electrochemical response was amplified by combination with a DNA circuit, in which the target DNA served as a catalyst. This system did not require modification of a complementary DNA with the ferrocene-modified probe on the electrode surface to separate the bound/free probe for detection of 200 nM target DNA.

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