Primary liposarcoma of the stomach is rare and only seven cases have been described in the English literature. Here we report the eighth case, which occurred in a 68-year-old woman who presented with repeated tarrystools andhematemesis. Endoscopic examination revealed a large ulcerated submucosal mass atthe gastric angle. Thepatient wastreated bytotal gastrectomy. On microscopic examination, the tumor showed the features of a well differentiated sclerosing liposarcoma. Immunohistochemically, many spindle to stellate tumorcells were diffusely positive for vimentin and CD34. Positivity for 8-100 protein was found in the adipocytic component, including lipoblasts, in addition to some spindle-shaped tumor cells. On ultrastructural examination, the spindle to stellate cells had features characteristic of fibroblasts. No recurrence or metastasis wasseen during 13 months. Liposarcoma of the stomach has to be considered in thedifferential diagnosis with other submucosal lesions, such asgastric lipoma and gastrointestinal stromal tumor.

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