The factors predisposing to diseases in Nigeria, Sub-Saharan was classified basically as animal, environmental, cliental among others. This review   was aimed at broadening the horizon of the Veterinarian. These factors were discussed in the light perspective of the peculiarity of Nigeria being a developing country. The write- up also proffered some solutions using organic botanicals agents which are relatively safe in food animals with little residual effect. Some of the plants suggested are: Allium sativm, Curcuma longa, Discorea japonica, Ziginber officinale, Jatropha gossipofolia, Datura spp  and Boerhaavia diffusa. Supplements suggested are ascorbic acid, citric acid and Vitamin E. Immunomodulating supplements suggested are interferons, L-carnitine. The immunomodulating and immunostimulating agents suggested could be used in immunocompromised animals due to contemporary predisposing factors to diseases in this geographical region.