Aim: This study is aimed to measure the value of serum Mac-2 binding protein glycan isomer (M2BPGI) in children with chronic liver diseases in comparison with liver biopsy and serum biomarkers. Methods: Comparative cross-sectional study included 100 children with chronic liver diseases and 50 healthy age/sex-matched control group. All subjects were evaluated via medical history, clinical, radiological and laboratory examinations. Liver biopsy was performed for studied patients and serum M2BPGI level was measured by Enzyme Linked Immune Sorbent Assay (ELISA) in all studied subjects. Results: Serum M2BPGI level increased more significantly in chronic liver disease patients (6.04 � 2.72 ng/ml) than in healthy controls (1.12 � 0.83 ng/ml) (P < 0.001). M2BPGI level was significantly elevated with progressive fibrosis (P < 0.001), and differed significantly between high and low Child-Pugh score, pediatric end-stage liver disease score and model for end-stage liver disease score score. Serum M2BPGI was correlated with serum biomarkers and degree of fibrosis in patients. Conclusion: M2BPGI could be used as one of noninvasive tools for detecting and staging of hepatic fibrosis in Egyptian children with chronic liver disease.

Introduction: Interestingly, health care professionals have the tendency to focus on the biological dimension of the disease or other technical issues related to hemodialysis machine and usually underestimate symptoms from mental sphere. Encouraging patients to express their feelings and addressing their psychological needs may be an essential measure to confront with this debilitating disease. Aim of Study: The objective of our study were to assess the presence, possible factors related and consequences of psychological disorders in children with CKD on regular hemodialysis. Methods: This study was cross sectional study which carried out in nephrology unit of the pediatric department during the period from February 2019 to December 2019.It were comprised (141) children with CKD on regular hemodialysis of both sexes after obtaining informed consent from children's parents. All patients were subjected to history (age, sex, residence, birth order, level of education, socioeconomic status), examination and specific investigations. Results: This study showed that, a male predominance. Regarding anxiety grade, mild were 18 (12.8%), moderate were 54 (38.3%) and severe were 69 (48.9%). Regarding depression grade, mild were 50 (35.5%), moderate were 54 (38.3%), and severe were 19 (13.5%) while no depression was found among 18 (12.8%).There were statistically significant positive correlations between anxiety score and duration of dialysis. There were statistically significant positive correlations between anxiety score and depression score. Conclusion: Frequency of anxiety and depression is high in CKD Patients. There were statistically significant positive correlations between anxiety score and depression score.

No abstract

No abstract

No abstract