The article deals with issues of correcting insulin resistance in polycystic ovary syndrome. It has been shown that on the one hand, an increased level of insulin leads to an intensification in the processes of fat synthesis and to blocking of fat decay. On the other hand, an increase in the volume of fat cells is accompanied by a decrease in the density of insulin receptors on their surface and an increase in insulin resistance. Against the background of hyperinsulinemia and insulin resistance, activation of the synthesis of pro-inflammatory cytokines and cytokine-like substances is observed.