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Interaction of 2-[1-(4,6-dimethoxybenzofuran-5-yl)ethylidine]malononitrile (1) with phenylisocyanate, phenylhydrazine, carbon disulphide and arylidenemalononitrile afforded the corresponding pyridine 2, pyrido[2,3-d] pyrimidine 3, phenylhydrazone 4, pyridine 2,6-dithione 8 and benzene dicarbonitrile 9 derivatives . Treatment of 1 with elemental sulfur under Gewald reaction conditions furnished 2-amino-4-(4,6-dimethoxybenzofuran-5-yl)thiophen-3-carbonitrile 11 which used as starting material in the synthesis of thienopyrimidine 14 and thienopyridine 15 derivatives.

Fused pyrimidine derivativesFused pyrimidine derivatives R 0515 Reaction and Antimicrobial Activity of 1-Arylethylene Benzofuranyl Ketone Derivatives. -Benzalvisnaginone and khellinone derivatives (I) are transformed into various pyrimidine, cyclohexanone and pyranone derivatives. Some products are evaluated for their antimicrobial activity: derivatives (V) and (VII) show significant antibacterial effects. -(MICKY*, J. A. A.; SALEH, N. M.; MOHAMED, S. M.; MOHAMED, S. A.; SALEM, M. M.; Indian J. Chem., Sect. B: Org. Chem. Incl. Med.