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This study examined circulating Þ larial antigen by monoclonal antibody Og4C3-enzyme-linked immunosorbent assay (ELISA) from 114 men with hydrocele, living in an endemic area. Nocturnal blood and hydrocele ß uid were collected and examined for microÞ laria. ELISA was performed on serum and hydrocele ß uid for detection of antigen. Amongst 114 cases, 5(4.4%) showed microÞ laria in blood but none in ß uid. ELISA was positive in 13(11.40%) serum and 5 (4.4%) ß uid samples. All Þ ve ß uid antigen positive cases were positive for antibodies and showed microÞ laria in blood. These Þ ndings emphasize the use of circulating Þ larial antigen detection and alternative usage of hydrocele ß uid for diagnosis of Þ lariasis.

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