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Methods were developed [br the synthesis of 2-butytthio-2-oxo-1,3,2-oxazaphosphorinane, 2-butylthio-2-thioxo-1,3,2-.dio• and 2-butytthio-2-thioxo-1,3,2-diazaphosphor-inane, as well as of acyclic S-butyl O-ethyl (diethylamido)phosphorothioates and -dithioates and S-butyl bis(diethytamido)phosphorodithioate. These compounds can serve as models of possible metabolites of cyclic compounds. Based on the data obtained in studies of the antiesterase activity of the resulting compounds and their synergistic activity in mixtures with permethrine, a possible mechanism of in vitro and in vivo biological action of diheteraphosphorinanes was proposed.Key words: 2-bulylthio-2-thioxo-l.3.2-dioxaphosphorinane.2-butylthio-2-thioxo-l,3,2-diazaphosphorinane, 2-but,/lthio-2-o•215 S-butyl O-ethyl (diethylamido)phosphorothio:nes and -dithioates, S-butyl bis(diethylamido)pho~phorodithioate, inhibition of esterases, synergists for permethrmc, mechanism of action.Previously, l we have reported the synthesis and physiological activity of 1,3,2-oxazaphosphorinane derivatives (1 and 2), among which active nematocides and synergists for insecticides of the pyrethroid group have been found.

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