Цель. Показать на клиническом примере из кардиохирургической практики необходимость проведения исследований для определения генетической резистентности к антиагрегантным препаратам.

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The incidence of arterial thrombosis in patients with COVID-19 is about 11 %. Currently, the pathogenesis of these complications has not been fully studied. Purpose: present the course of COVID-19 Associated thrombosis of the left iliac artery on a clinical example. Material and methods. Patient with Covid-19 developed thrombosis the iliac artery. Results. A clinical example demonstrates that a patient with risk factors – coronary heart disease, type 2 diabetes mellitus, obesity, smoking, against the background of a new coronavirus infection, an iliac artery thromboembolism developed. Conservative treatment of thrombosis with antithrombotic drugs was not successful. In this connection, the patient was hospitalized in a socialized medical institution, where a thromboectomy was performed from the iliac, femoral, popliteal artery on the right. The patient's condition improved during the therapy. However, on the 3rd day, a pneumonia clinic developed, which was the reason for transferring him to a covid hospital. Despite the etiotropic and antithrombotic therapy, repeated arterial thrombosis of the vessels of the lower limb progressed, which required surgical intervention (amputation of the lower leg). The cause of death of the patient was a progressive multiple organ. A clinical example shows that the pathogenesis of thrombosis in COVID-19 has not been fully studied (not established), and treatment regimens with antithrombotic drugs require further revision.

Current international standards recommend every laboratory to develop or confirm the existing in literature reference intervals for each laboratory value. We studied aggregation platelet function in 128 apparently healthy men and women of Astrakhan region (Russia) in clinical and diagnostic laboratory of Federal Center for Cardiovascular Surgery, Ministry of Health of the Russian Federation. The study involved impedance technique using aggregometer Multiplate (Verum Diagnostica, Germany), adenosine diphosphoric acid being used as an inductor. Age and gender had no significant effect on platelet aggregation values. Reference interval of platelet aggregation with adenosine diphosphoric acid on the aggregometer Multiplate in adult population of Astrakhan region was found to be 598.0-1,120.0 AU·min, where AU·min is the area under aggregation curve.The stated platelet aggregation interval in adult population can be used as reference in Astrakhan region laboratories when working with similar analytical systems (automatic aggregometer Multiplate), since it was developed considering all peculiarities of developing reference groups and standardization of all laboratory research stages.