Two patients with first trimester abortion and idiopathic cold agglutinin
syndrome due to cold auto-antibodies of the IgM and IgG immunoglobulin classes are
reported.
Sucrose gradient ultracentrifugation and 2-mercapto-ethanol treatment indicated the
presence of IgM as well as IgG cold agglutinins.
The possible relationship between the abortions and these cold agglutinins is discussed.
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