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Osteogenesis Imperfecta (OI) is an inherited disorder characterized by extreme bone fragility due to collagen defects. It is an incurable disease. Bone fractures can occur frequently without prior notice, especially among children. Early quantitative prediction of fracture loads due to OI tends to alert patients to avoid unnecessary situations or dangerous conditions. This study is aimed at investigating the fracture loads of femur with OI under various types of loading. Ten finite element models of an OI-affected bone were reconstructed from the normal femur with different bowing angles ranging from 7.5 to 30.0°. The boundary conditions were assigned on an OI-affected femoral head under three types of load: medial-lateral impacts, compression-tension, and internal-external torsions, and various loading direction cases that reflect the stance condition. The fracture load was examined based on the load that can cause bone fracture for each case. The results show that the loads bearable by the femur before fracture were decreased with respect to the increase of OI bowing angles in most of the loading cases. The risk of fracture for the femur with OI was directly proportional to the increase of bowing angles in the frontal plane. This study provides new insights on fracture load prediction in OI-affected bone with respect to various loading types, which could help medical personnel for surgical intervention judgement.