No abstract

The investigation of bioactive compound from Indonesian marine sponge Petrosia sp. has been done on February 2019. The bioactive compound isolated based on bioassay-guide dseparation with several steps of chromatography. The bioactive compound known as C16H25NS determined by LCMS-ESI with molecular weight [M+H] + 263.42 m/z. The FTIR spectrumshowd that the bioactive metabolite has alkane skeleton of hydrocarbonat 2982.58 cm−1andisonitrile functional group at 2115 cm−1. The result of NMR interpretation showed that the bioactive compound know as 4-amorphene with decalin as hydrocarbon skeleton with additional isonitrile moiety. The rate of viability show scytotoxic against NBT-T2 cell.

The study of search the bioactive compound from Indonesian Marine Sponge Petrosia sp. has been conducted on February 2019. The bioactive compound isolated based on bioassay-guided separation with several steps of chromatography. The compound known as C16H25NS determined by lCmS-ESI with molecular weight [M+H]+263.42m/z. The FTIR data showed that the functionality as hydrocarbon skeletone of alkane and isonitrile at 2982.58 cm−1 and 2115 cm−1, respectively. Furthermore, the NMR data confirm that the active compound knowns as 4-amorphene-10- isothiocyanate. The cytotoxic data indicate that the bioactive compound has activity against Panc-1 cell [IC50 = 0.1 μg / mL].The secondary metabolite from Indonesian marine sponge of Petrosia sp. has potential activity against human pancreatic cancer cells.