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Some 3-Hydrazono-2-indolinones and N-Mannich Bases as Potential Anticonvulsants.-A series of 3-hydrazono-2-indolinones, e.g. (III), and N-Mannich bases such as (VI) are synthesized and investigated for their anticonvulsant activity. It is shown that the introduction of bromo and morpholinomethyl substituents does not affect the desired activity. -(GUERSOY, A.; KARALI, N.; BUEYUEKTIMKIN, S.; DEMIRAYAK, S.; EKINCI, A. C.; OEZER, H.; Farmaco 51 (1996) 6, 437-442; Dep. Pharm. Chem., Fac. Pharm., Univ. Istanbul, TR-34452 Istanbul, Turk.; EN)

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Acylation of the quinazolinone derivatives (I) yields the N‐substituted compounds (III).

Quinazolinones.Part 18. Synthesis and H1/H2-Antihistaminic Activity of ω-(2-Aryl-2,3-dihydro-4(1H)-quinazolinon-1-yl)alkyl-Substituted Ureas and Cyanoguanidines. -The cyanoguanidines (V) and (IX) are obtained either by aminolysis of the O-phenylisourea precursors (III), generated by reaction of the alkylaminoquinazolinones (I) with the cyanimidocarbonate (II), or by direct aminolysis of N-cyano-S-methylisothiourea (VIII) with (I). A similar condensation reaction of (I) with the carbamate (VI) yields the ureas (VII). All compounds show only weak H1-antagonism, but some of them, especially (Vb), (Vd), and (VII), are more potent H2-antagonists than cimetidine.-(BUEYUEKTIMKIN, S.; BUSCHAUER, A.; SCHUNACK, W.; Arch. Pharm. (Weinheim, Ger.) 324 (1991) 5, 291-295; Fac. Pharm., Univ. Istanbul, Beyazit, Istanbul, Turk.; DE)