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Thirty-five antineoplastic agents were administered to adult house flies, Musca domestica L., by feeding or injection, and effects of the treatment on the flies' reproductive capacity were determined. For both sexes of the insect the most effective sterilants were alkylating agents: none of the hormonal drugs were active, but one antimetabolite sterilized females only. The category of miscellaneous antineoplastic agents contained several chemosterilants including L-asparaginase. the only known enzyme with insect-sterilizing effects.

Two methods for the preparation of anilinopyrylium salts are described. The conversion of these salts to pyrans, pyridines, and nitrobenzenes is discussed. Azepines, benzimidazoles, and benxotriazoles are readily obtained from the o‐aminoanilinopyrylium salts.