GM2 activator protein is a glycolipid transfer protein cofactor necessary for the hydrolytic degradation of GM2 ganglioside by fl-hexosaminidase A. Its absence in human tissue results in symptoms of type AB Tay-Sachs disease. The protein prepared by recombinant techniques using an E. coli expression system, has been crystallized by the vapor-diffusion technique. The crystals are well ordered and belong to the orthorhombic space group P2~2121. The unit-cell dimensions are a=42.40, b=39.82, c=113.61,A,. One molecule is contained in the asymmetric unit.

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