Purpose: The purpose of this study was to compare salivary immunoglobulin A (IgA) and total protein (TP) in patients suffering from oral lichen planus (OLP) and oral squamous cell carcinoma (OSCC), against healthy control. Methods: In a case-control study, 20 patients with OSCC, 30 patients suffering from OLP and 50 non-involved subjects were enrolled. The mean stimulated and unstimulated saliva IgA and TP levels were assayed by the Biuret method and immunoturbidometry respectively. Statistical analysis of the ANOVA was performed. Results: The mean concentration of stimulated and unstimulated saliva IgA and TP were significantly higher in both OLP and OSCC patients compared to control. Additionally TP, but not IgA, was higher in patients with OSCC compared with OLP patients d more salivary TP than OLP patients. Conclusion: Results suggest that salivary TP but not IgA is higher in OSCC patients than OLP patients.