No abstract

No abstract

ALTHOUGH EFFECTS Of anaesthetic agents on cardiac haemodynamics have been defined 1,'' until recently few data have been available concerning their actions on the peripheral circulation. In this regard, probably the best studied agent is halothane. Among the pertinent observations are decreased hepatic artery resistance in dogs, 3 decreased resistance in the canine hind limb, 4 decreased total peripheral resistance in man 5 and increased forearm blood flow in man. ~,~ All of these observations argue for peripheral vasodilatation, although Sawyer et al. 7 have shown peripheral vascular resistance to be increased by halothane in the miniature swine. On the other hand chloroform and eyelopropane have been shown to increase hepatic artery resistance ' while cyclopropane has been reported to increase splanehnic resistance in man ~ and to increase forearm vascular resistance in man. ~).1.

In man, azidomorphine, a new morphine congener, constricted pupils, produced morphine-like subjective effects and euphoria, and suppressed the morphine abstinence syndrome. Azidomorphine was 10 to 50 times as potent as morphine. It is concluded that in man azidomorphine is a typical morphine-like drug.