An analysis of changes in the hydrological indicators of the catchment area of the transboundary Shu River basin in the spatio-temporal aspect, based on information and analytical materials from the hy-drological posts of Kochkarka, Orto-Tokai, Milyanfan, Tashotkol, the Furmanovs hydroelectric com-plex and Ulanbel in a long period of observations covering 1931…2020, shows the presence of their constant fluctuations over the years under the influence of natural and anthropogenic factors. The hy-drological regime of the catchment area of the transboundary Shu River basin on a spatio-temporal scale with a positive or negative trend in the average annual water discharge is determined by the gen-eral nature of natural factors and changes due to increased anthropogenic activity on river systems. The results obtained indicate that the influence of natural and anthropogenic factors are less pronounced in the mountainous and foothill geographic zones than in the foothill-plain and desert zones of the catch-ment area of the transboundary river Shu.