was shown (p=0.62), if the sensor was placed intrahepatically. TPE increased when placing the sensor externally (p<0.01). Mean time for navigated targeting: 13.6 sec. TPE did not differ when targeting under continuous breathing versus in apnoe (p=0.08). Conclusion:This technique allows continuous intrahepatic tumour tracking and accurate and efficient targeting of liver lesions in an animal model. It might represent a simple approach for combined ablation and TACE in a single treatment session.