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Squamous cell carcinoma (SCC) is a malignant tumor with an estimated prevalence of 0.09% in Dakar. We report the case of a 40-year-old man with chronic lupus of the lower lip confirmed by histology and treated with topical corticosteroids and synthetic antimalarials for six years. He was hospitalized for an ulcerated and budding tumor of the lower lip evolving for six months whose histological study confirmed a squamous cell carcinoma. Complete surgical resection was performed and safety margins of 1 cm were excised with lymph node dissection under the mandible. The clinical result was favorable. Early surgical management has improved its prognosis.