Percutaneous x-ray endovascular angioplasty is one of the most modern methods of treatment of severe forms of cardiovascular diseases. In the pathogenesis of acute coronary syndrome, a special place is occupied by the proinflammatory reaction of the body. The main “secondary” marker is interlekin-6. The peak of its production occurs on the first day of damage and correlates with its size. The aim of the study. To investigate the dynamics of interleukin-6 level in the perioperative period of coronary revascularization, depending on the presence of acute coronary syndrome. Materials and methods. This study included 68 patients with coronary artery disease. The patients were divided into three study groups. Group 1 and 2 patients were diagnosed with ACS, and they underwent emergency stenting of coronary vessels in order to recanalize occlusion of the coronary arteries. 3rd group patients did not have ACS and they were recanalized as planned. Results. Analyzing the results of the study, we found that the highest obtained values of IL-6 were in group 1 in comparison with the group of patients who were surgically treated as planned and after stent placement, the interleukin values were 24.8 % higher in group 1 than in group 2 and almost 4 times higher in group 3 (p<0.001). When comparing groups with acute coronary syndrome, interleukin-6 indices were significantly higher by 47.4 % before surgery in group 3 and by 24.9 % after stent placement, which once again confirms the severity of patients with acute myocardial infarction. Conclusions. Intraoperatively proinflammatory interlekin-6 after coronary artery stenting tends to increase in groups with acute coronary syndrome, while in the group with stable angina, these indicators are significantly higher by 22.8 % (p <0.001). The dynamics of Il-6 levels clearly correlates with the severity of the patient's condition and increases in the presence of acute coronary syndrome, especially in the presence of acute myocardial infarction.

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The aim — to study the dynamics of troponin I level when conducting remote preconditioning in patients with severe clinical forms of acute coronary syndrome during percutaneous coronary recanalization of the infarct‑related artery.Materials and methods. The study involved 58 patients with severe forms of the clinical course of acute coronary syndrome who underwent stenting of the infarct‑related coronary artery. The age of patients ranged from 65.7 to 75.0 years (mean age — 68.2 ± 4.3 years). Among them were 42 men and 16 women. The average duration of anginal status before recanalization was 138.1 ± 11.52 min. Patients were divided into two groups. In the main group (n = 30) we used the method of remote preconditioning; in the control group (n = 28) — medication and interventional treatment according to the protocols adopted by the State Institution «Institute of Нeart of Ministry of Health of Ukraine» and Clinical Hospital «Feofania». Groups were homogeneous and statistically comparable.Results and discussion. The average content of troponin I in the main group was 31.2 ± 2.4 % less than in the control group. The postoperative level of troponin I in patients of the control group with cardiogenic shock was shifted to higher values, and in the main group — to smaller ones: in the main group there were 71.43 % more individuals with troponin I level from 0.44 to 1.0 ng/ml and 66.7 % less patients with troponin I level of more than 4 ng/ml than in the control group.Conclusions. The postoperative level of troponin I in patients with cardiogenic shock in the control group was shifted to higher values, while in the main group it was shifted to smaller values: in the main group there were no cases of an increase in troponin I to more than 4 ng/ml (in the control group there were 20 % of such cases). In the control group there were no patients with the level of troponin I less than 2 ng/ml (in the main group there were 12.5 % of such patients). A statistically significant difference between groups in troponin I content was 2 — 3 ng/ml (56.25 % cases in the main group and 6.7 % in the control group).