COVID-19 is a syndrome affecting pulmonary function but rather in serious conditions leads to death. Kencur (Kaempferia galanga L.) is a type of rhizome plant in Indonesia that is used as an herbal medicine called Jamu because it is believed to be able to cure various types of diseases. One of which is for anti-virus. The goal of this study was to see how effective the compounds in kencur are against COVID-19 with a molecular docking strategy. Kencur biological activities were obtained from the library and the design of the Acute Respiratory Syndrome Main protease (Mpro) has been gained from the protein data bank website. In addition, the biological activities in kencur were examined utilizing Lipinski's five-point concept was used to evaluate their substance molecular characteristics. Molecular docking analysis was performed with the PyRx Virtual Screening Tool software. The PyRx program was used for molecular docking simulation. While, the Discovery Studio Visualizer program was used to visualize the interaction between SARS-CoV-2 (Mpro) and the pharmacologically active metabolites in kencur. The docking evaluation on three antiviral substances revealed that Quercetin had the lowest binding energy when bound with Mpro and thus had the greatest potential as a viral inhibitor.
This paper considers and analyzes the results of examining samples for cadmium content by determining them on a Kvant-2AT atomic absorption spectrometer, taking into account the use of the PLP-01M microwave laboratory system and during sample preparation in accordance with GOST 26929 “Raw materials and food products. Sample preparation. Mineralization to determine the content of toxic elements”. The PLP-01M microwave laboratory system uses a fundamentally new method of sample preparation. The decomposition was carried out in a closed system - sealed fluoroplastic vessels under the influence of high temperature, pressure and microwave field. The microwave field in the working chamber of the furnace was created by a special generator-magnetron. Based on the results of the assessment of the operational control of the measurement procedure using samples for cadmium control during the implementation of the PLP-01M microwave laboratory system in the laboratory, the analysis procedure was recognized as satisfactory.
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