No abstract

The ability of 13-heptylglycoside muramyl dipeptide (glymuride) to stimulme nonspecific resistance in mice is studied. Glymuride prevents the death of up to 80% animals intraperitoneally infected with Salmonella typhi in a dose of 100 LD~ 0. Glymuride is effective in both oral and intravenous administration. The EDs0 for these routes of administration are calculated. Key Words: [5-heptylglycoside muramyl dipeptide; Salmonella typhi; nonspec(f~c resistanceSearch for new effective synthetic derivatives of bacterial muramyl dipeptide (MDP) has been in progress tor more than two decades. Several MDP analogs are now clinically tried, some including a Russian-made drug licopide, are used in clinical practice [3,6]. A perspective original muramyl peptide [3-heptylglycoside MDP (glymuride) stimulates the main components of the antitumor and antiinfectious immunity in model test systems in vitro [4,5,7]. Its effect is superior to that of non-modified MDP and its derivatives.We investigated the capacity of this drug to stimulate nonspecific antiinfectious immunity and prevent animal death caused by intraperitoneal Salmonella typhi infection and determined the EDs0 for oral and intravenous administration of glymuride.