No abstract

X-linked juvenile retinoschisis (RS) has previously been localized to a 7–8 cM interval between markers at (DXS43, DXS207) and (DXS274, DXS41). Our analysis of more than 300 meioses in two multigeneration RS families identified eight recombinant RS chromosomes and narrowed the RS locus to an interval between DXS987 and DXS443. Our data suggest the following order of loci: Xpter – DXS207 -DXS987 – ([DXS418 – DXS999], RS) – DXS443 – DXS365 – DXS274 – Xcen.