At 66 parts per million in the feed, robenzidene is highly effective in preventing chicken coccidiosis caused by any one of eight Eimeria species. Three times this dose is safe for broiler chickens. In dogs and rats, the toxicity was relatively low over a period of 90 days. In laboratory trials, the drug completely prevents oocyst production by seven species and greatly reduces oocyst production by Eimeria maxima.

A new antibacterial antibiotic, designated simaomicin a (LL-D42067a) was isolated from the fermentation broth of an actinomycete strain. Based on cultural, physiological, morphological and chemical characteristics, culture LL-D42067was identified as a newsubspecies of Actinomadura madurae. Simaomicin a demonstrated potent activity against Gram-positive bacteria and was active in vivo against a variety of Eimeria species causing coccidiosis in chickens.

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