In search of potential natural products for the amelioration of obesity, phytochemical investigation of leaves of Senna siamea Lam. was carried out. It led to the isolation of demethycassiarin B (1), 6,8-dihydroxy-3-methyl-1H isochromenone (2), and 6hydroxymellein (3). The structures were elucidated by a detailed analysis of spectral data.Compound 1 was found to possess a similar structural skeleton as that of cassiarin B except for a methoxyl substitution. Detailed HPLC and HPTLC analysis of methanolic extract for the presence of compound 1 and cassiarin B were performed. Cassiarin B was not detected in extract. Compounds 2 and 3 have been reported for the first time from the genus Senna. The isolated compounds were evaluated for their antiadipogenic activity in murine 3T3L1 cells.
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