We report a case of a child who developed acute disseminated encephalomyelitis after a trauma at home. This is a 25-month-old child, born of a non-consanguineous marriage with no perinatal history or any recent viral infections, with good psychomotor and intellectual development. Diagnosis of encephalopathy can be difficult in children, with nonspecific, subtle, and transient symptoms, such as drowsiness or irritability that can be easily overlooked, especially in the emergency department. The best available diagnostic tool is based on clinical and radiological findings. MRI could be useful for a precise and early diagnosis necessary to solve some unanswered questions.