IntroductionRenal cell carcinoma (RCC) accounts for 3% of adult malignancies and more than 90% of kidney neoplasms. High rates of undiagnostic percutaneous kidney biopsies and difficulties in reliable pre-operative differentiation between malignant and benign renal tumors using contemporary imaging techniques result in large numbers of redundant surgeries. Absence of specific biomarkers for early detection and monitoring complicates on-time diagnosis of the disease and relapse. For the patients followed up after having a nephrectomy, a noninvasive and sensitive biomarker enabling early detection of disease relapse would be extremely useful.Material and methodsThe study is a review of recent knowledge regarding potential clinical applications of microRNAs (miRNAs) as biomarkers of RCC.ResultsMicroRNAs are essential regulators of various processes such as cell proliferation, differentiation, development and death; they have been implicated in diverse biological and pathological processes in RCC. There is a class of miRNAs that promote RCC development (oncomirs) and a class of miRNAs that negatively regulate oncogenes, suppress tumor growth and invasion, and thus could be considered treatment agents (anti-oncomirs). Separate miRNAs and specific miRNAs expression profiles have been identified, enabling early detection of the disease, prediction of response to systemic therapy, or prognostication of biological behavior of the disease.ConclusionsThe miRNA network analysis and gene profiling may help to identify the most sensible molecular signatures of RCC that can be used for diagnostic purposes, as well as poor prognosis signatures and poor therapeutic response signatures in patients who undergo systemic therapy.

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Goal. Identify the effective criteria for drought tolerances of leguminous crops, based on their basis evaluate the recommendation for cultivating soybean cultivars and discuss the mechanisms of resistance on the organism and molecular levels. Methods. The collection and breeding genotypes of soybean, chickpea and pea were grown in field and laboratory experiments as well as cultivars included in the State register of plant varieties suitable for dissemination in Ukraine. The reaction of soybean plants on the effect of water stress was determined in climatic chambers at the temperature of 30–32 °C. Results. The genetic variability in absorption of water by seeds of various soybean cultivars was detected especially at the initial stages of soaking. The tolerance to drought is associated with the level of free proline accumulation and water-keeping proteins in the leaves, the area of the leaf surface, the loss of moisture by the plant for a certain period, the development of the root system. Soybean cultivars Arcadia odesskaya and Hodson distinguished by increased resistance to drought. Conclusions. Tested in the field and laboratory conditions methods for determining resistance to water stress may be recommended for use in breeding research with agricultural crops. Keywords: breeding of leguminous crops, drought tolerance, adaptability to high temperature.

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