Relevance. Duodenal ulcer is complicated by perforation in 5-15% of patients. The priority area of abdominal surgery is the introduction of minimally invasive methods. Laparoscopic surgeries are becoming an alternative to standard technologies. Objective: to analyze the effectiveness of open and laparoscopic palliative and conditionally radical surgical interventions in patients with perforated duodenal ulcer in the early and late two-year periods. Materials and methods. The efficacy of open and laparoscopic palliative and conditionally radical surgical interventions was studied in 181 patients with perforated duodenal ulcer in the early and late two-year periods. The patients were divided into two groups: 92 patients who underwent laparoscopic surgery and 89 patients who underwent open surgery. The groups are comparable in age, time from the onset of the disease, and the diameter of the ulcer. After the operation, the intensity of pain was assessed in points using a visual analog scale, the rate of healing. Complications in the early postoperative period were analyzed (wound suppuration, pneumonia, extrasystole, atrial fibrillation, abscesses, suture failure). Analyzed the development of peritonitis and its characteristics (serous-fibrinous, fibrinous-purulent; local, general). Results. Laparoscopic operations take less time than open ones. In the first four days after surgery, the average pain score was significantly lower (p<0.05) in patients after minimally invasive surgery. There was a tendency towards earlier activation of patients in the group of laparoscopic operations. The duration of hospital stay after laparoscopic operations averaged 5.11±0.08 days (from 3 to 7 days) and was significantly less (p<0.05) for that in patients who underwent open surgery. The two-year cumulative incidence of ulcer recurrence in the group of laparoscopic operations was 16.3% (15 patients), in the group of open operations - 19.1% (17 patients). Conclusions. Laparoscopic palliative and conditionally radical surgeries in patients with perforated ulcers have advantages in the early postoperative period, which is associated with minor pain syndrome and earlier activation of patients and, as a consequence, a decrease in the length of hospital stay. In the long-term two-year postoperative period, the results of palliative and conditionally radical operations in the laparoscopic and open versions did not differ significantly.