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In vitro experiments performed on rabbits showed that tris-2-(hydroxyethyl)ammonium orthocresoxyacetate (trecrezan) increases the cytokine activity of total tryptophanyl mRNA synthase (TRSase) via stimulation of the synthesis of a specific mRNA synthase (TRSase). This explains the mechanisms of the hypolipidemic, immunomodulatory, and adaptogenic actions of trecrezan.

The experiments reported here demonstrated that prophylactic use of trecrezan delayed the development of atherosclerosis in rabbits, with decreases in aortic atherosclerotic plaques and reductions in cholesterol, triacylglycerols, and b-lipoprotein levels in serum, liver, and aortic tissue. Trecrezan accelerated the synthesis of tryptophanyl tRNA synthetase, which is the key component in the complex mechanism of action of this agent.

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