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212ChemInform Abstract A large number of title compounds as well as some N-substituted aminoacridines are synthesized according to known procedures in moderate to good yields and tested for their pharmacological activity. Among them, the compounds (I) (local anesthetics), (IIa) (antihistaminic activity) and (IIb) (analeptic activity) are found to be the most active ones. The results for all products are tabulated. Witha view to determining relationship between the physico-chemical properties and the biological activities, pKa, lipophilicity and DNA binding of some compounds of each type are studied.